1060184000

Analysis Note

Purity (GC): ≥ 99.8 %Identity (IR): conformsEvaporation residue: ≤ 3.0 mg/lWater: ≤ 0.03 %Color: ≤ 10 HazenAcidity: ≤ 0.0002 meq/gAlkalinity: ≤ 0.0002 meq/gTransmission (at 225 nm): ≥ 50 %Transmission (at 240 nm): ≥ 80 %Transmission (from 265 nm): ≥ 98 %Filtered by 0.2 µm filter

Evaporation Number: 1.9

Application

Intended for HPLC and UHPLC-MS applications.Featured in method development of: Benazepril - USP Method Benazepril RS Betamethasone - USP Method Betamethasone Valerate Assay Irbesartan - USP Method Irbesartan Assay Lamivudine - USP Method Lamivudine RS Lansoprazole - USP Method Lansoprazole RS Levofloxacin - USP Method Levofloxacin RS - USP Method Levofloxacin Assay Nifedipine - USP Method Nifedipine RS - USP Method Nifedipine Assay PharmacopŒia Monograph Methods - HPLC and UHPLC methods for Regulated Drug Analysis Pioglitazone - USP Method Pioglitazone HCl RS - USP Method Pioglitazone HCl Assay

Features and Benefits

suitability tested and specified for UHPLC-MS and UHPLC-UV: for analytical flexibility specified quality in positive and negative in positive and negative electrospray ionization (ESI) and atmospheric-pressure chemical ionization-mass spectrometry (APCI-MS) for lowest detection limits and confidence in analyses for all important MS modes (test 1)R12;ESI/APCI (+) ﹤ 2 ppbR12;ESI/APCI (-) ﹤ 10 ppb lowest impurity profile: for interference-free baselines (test 2) microfiltered through 0.2 µm filter (test 3) to provide:R12;A long lifespan to filters and mechanical parts of HPLC systems––reduced risk of column clogging packaged in borosilicate glass bottles for minimized metal ion contaminations lowest levels of trace metal impurities for a minimum metal ion adduct formationR12;﹤5 ppb lowest level of polyethylene glycol (PEG) impurities in UHPLC-MS solvent lineup (PEG S/N signal-to-noise-ratio ﹤ 50)

General description

LiChrosolv^® solvents exhibit high degree of UV transmittance, low particle count, low acidity and alkalinity and low evaporation residue level. This makes them ideal for reproducible separations.

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Packaging

10, 185, 30 l in Barrel stainl. st.

2.5, 4 l in Glass bottle

5 l in Aluminium Bottle

Preparation Note

Product filtered through a 0.2 µm filter

assay	≥99.8% (GC)
autoignition temp.	725 °F
bp	64.7 °C (lit.)
color	APHA: ≤10
density	0.791 g/mL at 25 °C (lit.)
evapn. residue	≤3.0 mg/L
expl. lim.	36 %
form	liquid
grade	isocratic
impurities	≤0.03% Water, ≤0.0002 meq/g Alkalinity, ≤0.0002 meq/g Acidity
InChI key	OKKJLVBELUTLKV-UHFFFAOYSA-N
InChI	1S/CH4O/c1-2/h2H,1H3
kinematic viscosity	0.54-0.59 cSt(20 °C)
mp	−98 °C (lit.)
potency	17100 mg/kg LD₅₀, skin (Rabbit), 5628 mg/kg LD₅₀, oral (Rat)
product line	LiChrosolv^®
Quality Level	100
refractive index	n20/D 1.329 (lit.)
SMILES string	CO
storage temp.	2-30°C
technique(s)	HPLC: suitable
transition temp	flash point 9.7 °C
transmittance	265 nm, ≥98%, 240 nm, ≥80%, 225 nm, ≥50%
vapor density	1.11 (vs air)
vapor pressure	97.68 mmHg ( 20 °C), 410 mmHg ( 50 °C), 128 hPa ( 20 °C)