Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Omentin (intelectin-1) has been used in intelectin binding and cleavage assays.

Biochem/physiol Actions

Omentin (intelectin-1) has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. It increases protein kinase B (AKT) phosphorylation in the absence and presence of insulin. Omentin was suggested to play a role in the defense system against microorganisms by recognizing carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues. It has anti-inflammatory and insulin-sensitizing properties. The protein may be a biomarker of metabolic disorders. It has been shown to be over-expressed in human malignant pleural mesothelioma (MPM).

General description

Omentin (intelectin-1) is highly expressed in omental adipose tissue, small intestine and various other tissues. It is a plasma adipokine made up of 313 amino acids.

Legal Information

FLAG is a registered trademark of Sigma-Aldrich Co. LLC

Other Notes

Human omentin (aa 17-313) is fused at the N-terminus to a FLAG^®-tag.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 µL deionized water.