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Biochem/physiol Actions

CK1δ is a regulator of Yes-associated protein (YAP) transcription coactivator, which is a key regulator of organ size and a candidate human oncogene. CK1d is activated by CCK2R and it then phosphorylates polycystin 2 (PKD2) at Ser244. Phosphorylation of PKD2 leads to its nuclear accumulation and efficient phosphorylation of nuclear PKD2 substrates in human gastric cancer cells. CKId can phosphorylate in vitro deoxycytidine kinase (dCK), which is a key enzyme in the salvage of deoxynucleosides. Phosphorylation of dCK by CKId in vitro correlates with increased activity of this enzyme.

General description

Casein kinase 1 δ (CK1δ) is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair.

Legal Information

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Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles