Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

FGF-acidic is one of 23 known members of the FGF family. Recombinant rat FGF-acidic is a 15.9 kDa protein consisting of 141 amino acid residues.

General description

Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors.

Physical form

Lyophilized from 10 mM Sodium Phosphate, pH 7.2 + 150 mM NaCl + 0.2% CHAPS.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in 5 mM Sodium Phosphate, pH 7.2 to a concentration of ≤0.5 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.