Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Increased expression of resistin-like molecule-β (RELM-β) in asthmatic airways is associated with pulmonary inflammation and airways remodeling in the mouse. It increases deposition of matrix proteins via enhancing fibroblast proliferation and differentiation. RELM-β is implicated in interleukin 13 (IL-13) induced antiparasitic activity. RELM-β plays a vital role in the regulation of colonic epithelial cell barrier function and gastrointestinal innate immunity. Decreased expression of RELM-β leads to colonic inflammation.

General description

Resistin-like molecule-β (RELM-β), also known as found in inflammatory zone-2 (FIZZ-2), is a member of RELM/FIZZ family of cysteine-rich secretory proteins. Recombinant murine RELM β is an 18.0kDa, consisting of two 83 amino acid residue chains. RELM-β contains highly conserved C-terminal domain and the molecular structure is highly homologous to that of adipose-derived cytokine resistin. It is a disulfide-linked homodimeric protein synthesized and secreted by goblet cells in intestine. RELM-β is expressed in the lumen of the bowel and epithelial cells of the intestine.Recombinant Murine RELM beta is an 18.0kDa, consisting of two 83 amino acid residue chains.

Physical form

Lyophilized from 10 mM Acetic Acid.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Sequence

MQCSFESLVD QRIKEALSRQ EPKTISCTSV TSSGRLASCP AGMVVTGCAC GYGCGSWDIR NGNTCHCQCS VMDWASARCC RMA