Non disponible en dehors du Royaume-Uni et de l'Irlande

Amino Acid Sequence

Mu-His-Ser-Ser-Lys-Leu-Gln-AMC

Application

Prostate Specific Antigen Substrate has been used to assay recombinant severe acute respiratory syndrome coronavirus-2 viral 3-chymotrypsin-like cysteine protease (SARS-CoV-2 3CLpro).

Biochem/physiol Actions

Prostate specific antigen (PSA). It exhibits chymotrypsin-like activity. PSA is the most abundant proteasefound in the prostate and secreted into the seminal fluid. It is a useful biomarker for prostate cancer. PSA digests the gel-forming proteins semenogelins I and II in semen. It shows antiangiogenic activityin vitroandin vivo.

General description

Prostate specific antigen (PSA) is a kallikrein-related serine peptidase that belongs to the chymotrypsin subfamily serine protease. It was originally found in human semen. PSA is also detected in serum correlated to benign and metastatic disease.