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Amino Acid Sequence

Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ala-NH2

Application

Myosin Light Chain Kinase Substrate (smooth muscle) has been used in MLCK activity assay to study the role of Plasmodium falciparum calmodulin (Pf CaM).

Biochem/physiol Actions

KKRAARATSNVFA-NH2 is used as a myosin light chain kinase (MLCK) substrate.

Myosin light chain kinase (MLCK) is involved in modulating the actin-myosin interaction of smooth muscle. In addition to its kinase activity, MLCK also has actin-binding activity, which can assemble actin filaments into bundles. It also has myosin-binding activity, which can generate myosin filaments.

General description

Myosin light chain kinase (MLCK) comprises an N-terminal actin-binding domain, a central kinase domain, and a C-terminal myosin-binding domain.