Non disponible en dehors du Royaume-Uni et de l'Irlande

Amino Acid Sequence

Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp

Application

Gastrin I (1-14) has been used:as a component of gastric cancer stem/progenitor cell (GCSPC) medium for tumorsphere cultureas a supplement in organoid growth medium (OGM) for patient-derived organoid (PDO)in viable lymphocytes culture for re-stimulation assay

Biochem/physiol Actions

Gastrin is a linear polypeptide that induces the secretion of gastric acid (HCl) by parietal cells.

The peptide gastrin I (1-14), which lacks a basic site, forms positive ions. Gastrin promotes the production and liberation of histamine in enterochromaffin-like cells through cholecystokinin 2 receptor (CCK2R). It also stimulates the release of gastric acid in parietal cells via the CCK2R receptor. Gastrin plays a key role in Zollinger-Ellison syndrome. It may play a role in the development of colorectal carcinoma.

General description

Gastrin, a classic digestive hormone, is found in three major forms: gastrin-34 (big gastrin), gastrin-17 (little gastrin), and gastrin-13 (minigastrin). Mammalian gastrin consists of a C-terminal four amino-acid sequence and a sulfated tyrosine 7 residue from the C-terminus. Gastrin is mostly found in the G cells of the stomach mucosa. Nutrients and gastrin-releasing peptides stimulate the release of gastrin.