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Biochem/physiol Actions

FMS also called CSF1R colony stimulating factor 1 receptor, and its ligand CSF1 are linked to poor prognosis in patients with solid tumors, and in patients with female reproductive cancers. In breast cancers with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).

General description

FMS, also called CSF1R colony stimulating factor 1 receptor, acts as a receptor for CSF1, and they both as key regulators of monocyte and macrophage functioning. It is a member of the platelet-derived growth factor (PDGF) family of proteins, and is a type III RTK (receptor tyrosine kinase). It is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain, and kinase insert domain (KID) intersecting the kinase domain.

Legal Information

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Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.