Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

EPHB3 is a member of the Ephrin receptor family and is expressed during embryonic development in multiple regions of the central nervous system. In adult brain, EPHB3 is expressed in the cerebellum, raphe pallidus, hippocampus, entorhinal cortex, and both motor and sensory cortices. EPHB3 is involved in the maintenance of mature neuronal connections and/or re-arrangement of synaptic connections during late stages of development. EPHB3 plays a role in the regulation of cell adhesion and migration, and the catalytic activity of EPHB3 is required for inhibition of integrin-mediated cell adhesion.

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Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.