Non disponible en dehors du Royaume-Uni et de l'Irlande
Amino Acid Sequence
Z-Leu-Leu-Nva
Biochem/physiol Actions
Potent inhibitor of the 20S proteasome (Ki = 21 nM) and 26S proteasome (Ki = 35 nM). Cells treated with 54 µM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.
Packaging
1, 5 mg in serum bottle
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