Peptide inhibiteur Autocamtide 2, > = 97 %( HPLC), poudre lyophile

Code: a4308-1mg D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Amino Acid Sequence

Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

Application

Autocamtide 2-related inhibitory peptide has been used:To inh...


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$295.41 1MG
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Non disponible en dehors du Royaume-Uni et de l'Irlande

Amino Acid Sequence

Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

Application

Autocamtide 2-related inhibitory peptide has been used:To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophagesTo study its influence on oxidative stress associated with neural cell death after hypoxia-ischemia, using neonatal hippocampal slice culturesTo quench the phosphorylation of recombinant synGA (GTPase-activating protein) induced by CaMKII

Biochem/physiol Actions

Potent inhibitor of calmodulin-depentent protein kinase II.

Calmodulin kinase II facilitates the calcium-dependent L-type calcium channels. Autocamtide 2-related inhibitory peptide action does not influence cAMP (cyclic adenosine monophosphate)-dependent protein kinase II, calmodulin-dependent protein kinase IV and protein kinase C. Increased expression of calmodulin kinase II is observed in structural heart disease, indicated by myocardial infarction. Thus, inhibition of calmodulin kinase II activity might serve as a protective effect against structural heart disease, as it is found to prevent cardiac hypertrophy, dilation and dysfunction.

assay≥97% (HPLC)
biological sourcesynthetic
compositionPeptide content, ≥70%
formlyophilized powder
Gene Informationhuman ... CAMK2A(815), CAMK2B(816), CAMK2D(817)mouse ... CAMK2A(12322), CAMK2B(12323), CAMK2D(108058)rat ... CAMK2A(25400), CAMK2B(24245), CAMK2D(24246)
InChI keyCOEHZSYVSXUBHI-CYZNULJVSA-N
InChI1S/C65H114N20O21/c1-32(2)28-46(63(105)106)85-54(96)36(7)78-62(104)45(31-52(93)94)84-56(98)38(33(3)4)30-47(86)34(5)76-59(101)43(19-22-50(89)90)81-55(97)37(18-21-49(69)88)29-48(87)40(16-12-26-74-64(70)71)79-60(102)42(17-13-27-75-65(72)73)83-61(103)44(20-23-51(91)92)80-53(95)35(6)77-58(100)41(15-9-11-25-67)82-57(99)39(68)14-8-10-24-66/h32-46H,8-31,66-68H2,1-7H3,(H2,69,88)(H,76,101)(H,77,100)(H,78,104)(H,79,102)(H,80,95)(H,81,97)(H,82,99)(H,83,103)(H,84,98)(H,85,96)(H,89,90)(H,91,92)(H,93,94)(H,105,106)(H4,70,71,74)(H4,72,73,75)/t34-,35-,36-,37+,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1
mol wt~_1.5 kDa
Quality Level200
SMILES stringCC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)CC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O
solubilityH2O: soluble
storage temp.−20°C
Cas Number167114-91-2
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