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Biochem/physiol Actions

Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin) and improves systemic metabolism by increasing energy expenditure. It is mainly responsible for the conversion of white fat into brown fat. This conversion enhances metabolic uncoupling and caloric expenditure. Irisin is always associated with beneficial responses of exercise on cellular metabolism. In obese and type 2 diabetic patients, low levels of circulating irisin are characteristic of the adipose tissue and muscle.

General description

Irisin is an described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin is cleaved from the type I membrane protein FNDC5 (fibronectin type III domain containing 5). FNDC5 is mainly expressed in the muscles. Low levels of the mRNA are also present in the kidney, liver and lung. The gene encoding irisin is mapped to human chromosome 1p35.1.

Legal Information

FLAG is a registered trademark of Sigma-Aldrich Co. LLC

Other Notes

Irisin (human, aa 16-127 /mouse, aa 29-140) is Flag-tagged at the N-terminus. Irisin has 100% identity betwen mouse, rat, monkey and human.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 µL deionized water.