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Biochem/physiol Actions

It also stimulates the production of proinflammatory mediators : nitric oxide, interleukin 1 (IL-1), IL-6, IL-8, and tumor necrosis factor α.

FliC (flagellin) can activate the innate immune system by TLR5 (toll like receptor 5) and is an important proinflammatory molecule. FliC also induces the production of antibodies and is identified as an antigen by CD⁴⁺ T cells.

General description

The encoded flagellin filament contains 55kDa monomers.

FliC (flagellin) is the subunit protein which polymerizes to form the filaments of bacterial flagella. The protein has four-domains (D0, D1, D2, D3).

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 µL deionized water.