Non disponible en dehors du Royaume-Uni et de l'Irlande

General description

DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.

Other Notes

The Fc portion of human IgG1 is fused to the C-terminus of human DR6 (aa 42-351).

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 50 µL deionized water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.