Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1).

Biochem/physiol Actions

Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C.

General description

Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns.

Other Notes

Recombinant human annexin V fused to a GST-tag.

Physical form

Lyophilized from PBS, pH 7.4.

Reconstitution

Reconstitute with 100 µL deionized water.