Non disponible en dehors du Royaume-Uni et de l'Irlande

General description

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Legal Information

FLAG is a registered trademark of Sigma-Aldrich Co. LLC

Other Notes

Signal peptide and mouse progranulin (aa 1-589) are fused at the C-terminus to a FLAG^®-tag.

Physical form

Solution in PBS.