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Biochem/physiol Actions

Hematopoietic progenitor kinase 1 (HPK1) acts as a tissue-specific upstream activator for the stress-activated protein kinases (SAPK)/Jun amino-terminal kinases (JNK) signaling pathway. By phosphorylating SH2 domain-containing leukocyte protein of 76 kDa (SLP-76), HPK1 effectively blocks the T cell receptor (TCR) signaling. HPK1 is implicated in the inflammatory response and in the pathogenesis of systemic lupus erythematosus (SLE). It mediates the degradation of IκB and nuclear factor-κB (NF-κB) activation by activating inhibitor of nuclear factor-κB (IκB) kinase (IKK) complex.

General description

Hematopoietic progenitor kinase 1 (HPK1) belongs to the Ste20 serine/threonine kinase superfamily. It comprises a C-terminal citron homology (CNH) domain and a total of 13 tyrosines as potential phosphorylation residues. The HPK1 gene is mapped to human chromosome 19q13.

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Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Preparation Note

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.