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General description

Mutant version of EZH2 5- member complex with a Tyr-to-Asn mutation on amino acids 646 of the EZH2 protein. Complex of human EZH2 (GenBank Accession No. NM_004456), amino acids 2-end (Y646N*) with N-terminal His-tag, MW= 86 kDa, human EED (GenBank Accession No. NM_003797) (amino acids 2-end) with N-terminal Flag-tag, MW= 51 kDa, human SUZ12 (GenBank Accession No. NM_015355) (amino acids 2-end) with N-terminal His-tag, MW = 87 kDa, Human AEBP2 (GenBank Accession No. NM_153207) (amino acids 2-end) with N-terminal His-tag, MW= 53 kDa, and human RbAp48 (GenBank Accession No. NM_005610) (a-a 2- end) with N-terminal His-tag, MW = 48 kDa, co-expressed in Baculovirus expression system. *This mutation is often cited as Y641N in variant 3 GenBank Accession No. NM_001203247).