Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Kinase assays.

The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.

General description

The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23.

Legal Information

Brij is a registered trademark of Croda International PLC

Physical form

Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij^® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.

Unit Definition

One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.