Manumycine de Streptomyces parvulus,

Code: m6418-5mg D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Manumycin A from Streptomyces parvulus has been used to inhibit IκB kinase (IKK)b−nuclear κ-B essential modulator (NEMO) interaction in the homogeneous t...


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Votre prix
£376.00 5MG
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Manumycin A from Streptomyces parvulus has been used to inhibit IκB kinase (IKK)b−nuclear κ-B essential modulator (NEMO) interaction in the homogeneous time-resolved fluorescence (HTRF)-based binding assay.

Biochem/physiol Actions

Potent inhibitor of Ras farnesyltransferase.

Manumycin A is a natural monomeric epoxyquinoid. It has an ability to inhibit tumor necrosis factor (TNF) induced IκB kinase (IKK) activity in various cell types. In addition, manumycin A exhibits anti-tumor property by inhibiting farnesylation of oncogenic Ras.

Packaging

5 mg in glass bottle

assay≥97% (HPLC)
formpowder
InChI keyTWWQHCKLTXDWBD-YCWSEAROSA-N
InChI1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28?,29-,31+/m1/s1
Quality Level200
SMILES stringCCCC[C@@H](C)C=C(C)C=C(/C)C(=O)NC1=C[C@@](O)(C=CC=CC=CC(=O)NC2=C(O)CCC2=O)[C@@H]3O[C@H]3C1=O
solubilitymethanol: 9.80-10.20 mg/mL, clear, yellow to very deep yellow
storage temp.2-8°C
Cas Number52665-74-4
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