Non disponible en dehors du Royaume-Uni et de l'Irlande

Analysis Note

The bioactivity is measured by its ability to inhibit the IL-2-dependent proliferation of a human megakaryocytic leukemic cell line, M07e.

Biochem/physiol Actions

Interleukin-2 (IL-2), a cytokine, enhances Th (T helper) cell differentiation and effector responses. In addition, it helps in immune tolerance. IL-2 binds to the high affinity receptor, formed of IL2RA (interleukin 2 receptor subunit α), IL2RB (interleukin 2 receptor subunit β) and γ-chain. Polymorphism in IL2RA is associated with multiple sclerosis. Null mutation in IL2RA results in immune dysregulation.

Physical form

Lyophilized from a 0.2 µm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.