Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Factor Vaserves as a receptor and positive effector offactorXa. Hence it can efficiently help in the conversion of prothrombin to thrombin.

Factor V is a key component in blood coagulation systems, where deficiencies can inhibit thrombin generation and affect hemostasis. It has been used in studies of coagulopathic bleeding which occurs following injury and is a leading cause of hospital deaths.

General description

Factor V, a glycoprotein is usually seen in the alpha granules of platelets and in plasma.

Factor Va is the activated form of factor V and the cofactor of Xa. It is a component of the prothrombinase complex.

Linkage

View this factors role in the Coagulation Cascade

Physical form

Aqueous solution containing 50% (v/v) glycerol and 5mM CaCl₂

Unit Definition

One unit is equivalent to the Factor V activity in 1.0 mL of normal human plasma at pH 7.4 at 37 °C.