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Analysis Note

The biological activity is measured by its ability to induce chemotaxis of rat Y3 cells stably expressing hCCR3.

Biochem/physiol Actions

Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3. Mature recombinant human eotaxin-3 has a molecular mass of approximately 8.2 kDa and demonstrates chemotactic activity for eosinophils.

Eotaxin-3 is a potent attractant of eosinophils, and might be responsible for the accumulation of eosinophils in atopic diseases. As it is involved in the recruitment of eosinophils in inflammatory diseases, it, along with its receptor, might have potential as therapeutic target in inflammatory disorders, such as asthma. Demethylation results in increased expression of this gene, which in turn influences allergic reactions. This gene is overexpressed in bullous pemphigoid (BP), which results in the accumulation of eosinophils in skin lesions, thus, contributing to the pathogenesis of BP. Its expression is also elevated in the active lesions of patients with ulcerative colitis (UC) and Crohn′s disease (CD). Thus, it might play a role in the pathogenesis of UC, where its major source is colonic myofibroblasts.

General description

Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3. This gene is localized to human chromosome 7q11.2, which codes for a protein of 71 amino acids. It belongs to the small inducible cytokine subfamily A , which also includes eotaxin and eotaxin-2.

Physical form

Lyophilized from a 0.2 µm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.