Non disponible en dehors du Royaume-Uni et de l'Irlande

Amino Acid Sequence

Tyr-Ala-Gly-Nme-Phe-Gly-ol

Application

[D-Ala², N-Me-Phe⁴, Gly⁵-ol]-Enkephalin acetate salt or DAMGO has been used:for use as a positive control in the assay of G-protein activation with μ-opioid receptor, to assay the inhibition of cAMP inhibition by DAMGO for the determination of the suppression of contraction by opioid receptors to determine whether the peripheral application of DAMGO suppresses the hypertonic saline (HS)-induced masseter nociception in slightly anaesthetized rats

Biochem/physiol Actions

Enkephalin analog that is a selective agonist at µ-opioid receptors.

General description

[D-Ala², N-Me-Phe⁴, Gly⁵-ol]-Enkephalin acetate salt or DAMGO is a full agonist of the μ-opioid receptor. μ-opioid receptor is encoded by the OPRM1 gene, which has a predominant expression in reward-processing areas of brain. It acts as a receptor for endogenous opioids such as β-endorphin, encephalin, as well as foreign opioids such as morphine, heroin, and methadone.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.