Non disponible en dehors du Royaume-Uni et de l'Irlande

Amino Acid Sequence

Glp-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys-Lys-Cys-Arg-Cys-Tyr-Ser [Disulfide Bridges: 7-28, 13-33, 17-35]

Application

Charybdotoxin has been used:in the inhibition of endothelium-derived hyperpolarizing factor responsesin electrophysiological studies, as calcium channel blockersas a transport inhibitor

Biochem/physiol Actions

High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel blocker.

Potent and selective inhibitor of the Ca²⁺-activated K⁺ channel present in GH₃ anterior pituitary cells and primary bovine aortic smooth muscle cells.

Charybdotoxin (ChTX) is a scorpion venom, which blocks a voltage-gated potassium channel, by binding to the extracellular loop of the potassium channel.

Other Notes

Peptide found in the venom of the scorpion Leiurus quinquestriatus.