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Amino Acid Sequence

Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

Application

Corticotropin Releasing Factor human, rat has been used:as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explantsas a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cellsin the synthesis of the corticotropin-releasing factor(CRF)-TAMRA1mixturein chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus

Biochem/physiol Actions

Corticotropin-releasing factor modulates stress responses. It facilitate stress-stimulated activation of the hypothalamic−pituitary−adrenal system.

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.

General description

Corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, hypothalamusand amygdala.

Other Notes

Lyophilized from 0.1% TFA in H2O