Corticotropine facteur de libération antagoniste, >=97% (HPLC)

Code: c2917-.1mg D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Amino Acid Sequence

Asp-Leu-Thr-Phe-His-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Ala-Glu-Gln-Ala-Leu-Asn-Arg-Leu-Leu-Glu-Ala-NH2

Biochem/physiol Actions<...


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$178.16 EACH

Non disponible en dehors du Royaume-Uni et de l'Irlande

Amino Acid Sequence

Asp-Leu-Thr-Phe-His-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Ala-Glu-Gln-Ala-Leu-Asn-Arg-Leu-Leu-Glu-Ala-NH2

Biochem/physiol Actions

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF receptors over human CRF receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

Other Notes

Lyophilized from 0.1% TFA in H2O

assay≥97% (HPLC)
formpowder
Gene Informationhuman ... CRH(1392)mouse ... CRH(12918)rat ... CRH(81648)
Quality Level200
storage temp.−20°C
Cas Number99658-03-4
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