Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

For research use only. Not for use in diagnostic procedures.Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Folate receptor 1 (FOLR1) plays a vital role in folate transport across the blood–brain barrier through the choroid plexus. It is also essential for neural tube closure during embryogenesis. Mutation in the gene leads to the development of cerebral folate deficiency in a few families. Overexpression of the gene has been observed in some epithelial malignancies including medulloblastoma, ovarian, lung and breast carcinomas. FOLR1 acts as a potential biomarker and therapeutic target for medulloblastoma.

General description

The antibody pair provided in this kit recognizes human Folate Receptor Alpha.The folate receptor 1 (FOLR1) gene is mapped to human chromosome 11q13.4. The gene codes for a glycosylphosphatidylinositol protein that is attached to cell membranes. Folr1 is expressed in placenta, kidney tubules and choroid plexus.