Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

For research use only. Not for use in diagnostic procedures.Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Mouse IL-13 ELISA Kit has been used to measure the concentration of interleukin (IL)-13 in serological sampleand bronchoalveolar lavage fluids (BALFs).

Biochem/physiol Actions

Interleukin 13 (IL13) is up-regulated during parasitic infections and participates in host′s protective immunity against Schistosoma japonicum. This protein promotes eosinophil activation resulting in elevated specific IgE against adult and larval antigens. During acute infection it promotes egg expulsion through increased intestinal contractility. It acts as a liver protective agent where it promotes the formation of liver granulomas in a CD4⁺ T cell-mediated manner, which results in liver fibrosis. In airway disorders, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis lung disease, IL13 promotes the formation of airway goblet cells, resulting in excess mucus secretion, which in turn, is regulated by IL13-activated autophagy.

General description

The Mouse IL-13 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of mouse IL-13 in serum, plasma, cell culture supernatants and urine.

Immunogen

Recombinant Mouse IL-13

Other Notes

A sample Certificate of Analysis is available for this product.Please type the word sample in the text box provided for lot number.