Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)Human Amphiregulin ELISA Kit has been used to estimate the plasma concentration of amphiregulin by ELISA.

Biochem/physiol Actions

Areg (amphiregulin) stimulates growth-signaling pathways via EGF (epidermal growth factor) receptors. Areg participates in the organogenesis of mammary gland. It is regarded as a pro-oncogenic factor and contributes to tumor progression. Upregulation of the AREG gene is observed in cancer and resists chemotherapy. AREG reduces E-cadherin expression in order to promote invasion and progression of ovarian cancer.

General description

The Human Amphiregulin (AR) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human AR in serum, plasma, cell culture supernatants and urine.The AREG (amphiregulin) gene codes for a shedding ectodomain, derived from a transmembrane precursor of 252 amino acids. The encoded protein is released into blood or cellular vicinity through autocrine and paracrine. Areg is predominantly expressed in epithelial, mesenchymal cells and also by active immune cells. The AREG gene is mapped to human chromosome 4q13.3.

Immunogen

Recombinant Human Amphiregulin

Other Notes

A sample Certificate of Analysis is available for this product.Please type the word sample in the text box provided for lot number.