Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Human SHBG/Sex Hormone-binding Globulin ELISA Kit has been used to measure serum sex hormone-binding globulin (SHBG) in whole blood samples. It has also been used to quantify SHBG in maternal peripheral and umbilical cord blood.

Biochem/physiol Actions

Serum sex hormone-binding globulin (SHBG) can bind and transport sex steroids and aid in modulating their biological active fraction. Direct action of SHBG modulates sex steroid actions in target cells. A low level of SHBG is detected in women with polycystic ovary syndrome (PCOS). The SHBG ELISA kit can be used for the quantitative measurement of sex hormone-binding globulin in cell culture supernatants, plasma and serum.

General description

Serum sex hormone-binding globulin (SHBG) protein is a homodimer with a signal peptide and two laminin G-like domains. SHBG is produced by testis germ cells and released into the bloodstream by the liver. SHBG gene is located on human chromosome 17p13.1.