Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

For research use only. Not for use in diagnostic procedures.Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Angiopoietin-2 (ANGPT2) belongs to the family of angiogenic factors. ANGPT2 is a competitive antagonist of ANGPT1 and reduces vascular stabilization. ANGPT2 is a potent marker for liver cancer. ANGPT2 binds with tyrosine kinase with immunoglobulin-like and endothelial growth factor (EGF)-like domains 2 (Tie-2) and causes neoangiogenesis in liver cirrhosis. Upregulation of ANGPT2 might have an adverse effect on kidney physiology and function. Overexpression of ANGPT2 leads to endothelial damage and dysfunction resulting in diabetic nephropathy in diabetic patients. ANGPT2 is a potent marker for detecting lung cancer progression. Upregulation of ANGPT2 promotes signal transduction for tumor progression in epithelial ovarian cancer.

General description

The Human Angiopoietin-2 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Angiopoietin-2 in serum, plasma, cell culture supernatants and urine.

Immunogen

Recombinant Human Angiopoietin-2

Other Notes

A sample Certificate of Analysis is available for this product.Please type the word sample in the text box provided for lot number.