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Application

The analytical standard can be used as follows: Simultaneous analysis of amoxicillin and clavulanate potassium in pharmaceutical formulations by capillary electrophoresis (CE) combined with capacitively coupled contactless conductivity detection (C⁴D) Development of a stability-indicating high-performance liquid chromatographic (HPLC) method combined with mass spectrometry (MS) to measure amoxicillin, clavulanate potassium, and their impurities in their combined dosage forms Residue analysis of potassium clavulanate and amoxicillin trihydrate by a UV spectrophotometric method in their bulk, combined tablet formulations, and human urine samples HPLC method-based determination of meropenem and potassium clavulanate in the presence of their degradation impurities in intravenous solutions in combination with a diode array detector (DAD) Determination of amoxicillin and clavulanic acid by capillary zone electrophoresis (CZE) in their combined commercial formulations

Biochem/physiol Actions

β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.

General description

Potassium clavulanate is an oxapenam derivative and belongs to the group of β-lactamase inhibitors. It is used in combination with the penicillin group of antibiotics to give them resistance to β-lactamase.

Legal Information

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.