Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

NEP control of heat-killed Staphylococcus aureus can be used as a positive control with the PyroMAT^® System. It is to be used for Product Specific Validation (PSV) and routine testing to show that the system can detect non-endotoxin pyrogen contaminants in pharmaceutical products.

Features and Benefits

Endotoxin-free product at concentration of use in MAT

General description

The PyroMAT^® System uses cryopreserved Mono-Mac-6 (MM6) human monocytic cells as a source of monocytes. The response to a full range of pyrogens, including endotoxins and non-endotoxin pyrogens (NEPs)is determined by the measurement of interleukin-6 (IL-6) produced by the Mono-Mac-6 cells using ELISA. NEP control HKSA is a heat-killed preparation of Staphylococcus aureus, supplied in a lyophilized form. HKSA is a non-endotoxin pyrogen (NEP) that activates the TLR2 receptor of monocytes and can be used as a positive control with the PyroMAT^® System (Monocyte Activation Test for pyrogen detection).

Legal Information

PYROMAT is a registered trademark of Merck KGaA, Darmstadt, Germany

Specificity

TLR-2 agonist

Storage and Stability

Store unopened vials at 2-8°CDo not use unopened vials after expiration dateStore resuspended aliquots at -20°CShelf life of aliquots can be found on the technical datasheet