Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
Useful as an antidote in methanol and ethylene glycol poisoning.
4-Methylpyrazole hydrochloride has been used: as a cytochrome P450 2E1 inhibitoras cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cellsto inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells
Biochem/physiol Actions
4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.
Alcohol dehydrogenase inhibitor
Packaging
100, 500 mg in poly bottle
1 g in poly bottle
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