Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.

Biochem/physiol Actions

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

General description

Chemical structure: macrolide

Other Notes

Filipin contains 8 isomeric components, with filipin III as the major component.

Packaging

50 mg in glass bottle

25 mg in poly bottle