2-fluoroadénine - 9 - bêta-d-arabinofuranoside, synthèsed'ADN et inhibiteur de méthylation

Code: f2773-5mg D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

2-Fluoroadenine-9-β-D-arabinofuranoside (F-ara-A) has been used:to assess its interaction with kinase inhibitor UCN-01 in human leukemia cells (U937 and HL-60) an...


en savoir plus

Votre prix
£147.00 5MG

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

2-Fluoroadenine-9-β-D-arabinofuranoside (F-ara-A) has been used:to assess its interaction with kinase inhibitor UCN-01 in human leukemia cells (U937 and HL-60) and primary patient samplesto assess its influence on endothelial cells by apoptosis assay and human microvascular endothelial cells (HMECs) by cytotoxicity assayin comparative cytotoxicity studies with Alemtuzumab CDC in 17p13- chronic lymphocytic leukemia (CLL) patients

Biochem/physiol Actions

Fludarabine (the 5′-phosphate) is a prodrug that is converted to F-ara-A, which enters cells and accumulates primarily as the 5′-triphosphate. F-ara-A interferes with DNA synthesis and repair and induces apoptosis of cancer cells. F-ara-A also strongly inhibits DNA methylation, particularly methylation of cytosine in CpG dinucleotide sequences.

Packaging

5, 10 mg in glass bottle

Warning

The name fludarabine refers to 9-β-D-arabinofuranosyl-2-fluoroadenine 5′-phosphate, but is sometimes erroneously used for this compound, which lacks the phosphate.

Gene Informationhuman ... ADORA3(140)rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
InChI keyHBUBKKRHXORPQB-FJFJXFQQSA-N
InChI1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1
Quality Level200
SMILES stringNc1nc(F)nc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O
storage temp.2-8°C
Code
Description
Unité de vente
Prix annoncé
Qté
F2773-10MG
Unité:10MG
Prix annoncé: £264.00
Source:Prix annoncé
Cas Number21679-14-1
Ce produit répond aux critères suivants: