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Biochem/physiol Actions

PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression.

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC₅₀ = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.