Adenine 9 - beta-d-arabinofuranoside,>=99 %

Code: a5762-1g D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Adenine 9-β-D-arabinofuranoside has been used for the inhibition of 5′ AMP-activated protein kinase (AMPK) in liver, muscle and cardiac cells H9c2.

Used to...


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£269.00 1G
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Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Adenine 9-β-D-arabinofuranoside has been used for the inhibition of 5′ AMP-activated protein kinase (AMPK) in liver, muscle and cardiac cells H9c2.

Used to study the roles of AMP-activated protein kinase (AMPK) in cell signaling.

Biochem/physiol Actions

Cell-permeable adenylate cyclase inhibitor; in detergent-dispersed rat brain preparation, IC50 = 30 µM. Clinically significant antiviral agent, especially against herpes simplex (HSV), by inhibition of DNA polymerase.

General description

Adenine 9-β-D-arabinofuranoside (AraA) is a nucleoside analog. It is an antiviral drug and targets viral DNA polymerases and is majorly used for treating herpes simplex viral infection. It is a potent inhibitor of AMP-activated protein kinase (AMPK). It also inhibits cardiac type 5 adenylyl cyclase but does not improve pathology in cardiovascular diseases.

antibiotic activity spectrumviruses
assay≥99%
formpowder
Gene Informationmouse ... Ahcy(269378)
InChI keyOIRDTQYFTABQOQ-UHTZMRCNSA-N
InChI1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7+,10-/m1/s1
mode of actionenzyme | inhibits, DNA synthesis | interferes
Quality Level100
SMILES stringNc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O
storage temp.−20°C
Cas Number5536-17-4
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