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Analysis Note

Purity by agarose electrophoresis.

Application

Transferrin human has been used:to incubate human proximal tubule cells (HKC) - 8 cells along with IgG for the examination of albumin specificityas a supplement in serum-containing/devoid medium for human thyroid cell cultureas a target glycoprotein to develop an in-gel hydrazinolysis method

Biochem/physiol Actions

Transferrin mediates iron transportation from plasma to cells. The iron-bound transferrin are of three forms: monoferric A/B transferrin and diferric transferrin. The transferrin binds to specific cell surface receptors and are internalized by endocytosis. Once inside, the iron is released into the cells and the iron-free transferrin, also referred to as apotransferrin, is exocytosed outside the cell without being degraded. Transferrin is known to deliver iron to cells in a physiologically safe and effective form.

General description

Transferrin is a glycoprotein with a branched carbohydrate chain, having two sites for ferric ion binding in its polypeptide chain.

Other Notes

Partially iron-saturated

Preparation Note

Heat treated at 60 °C for ten hours.