Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

5-(2-Benzothiazolyl)-3-et﹤WBR>hyl-2-[2-(methylphenylami﹤WBR>no)-ethenyl]-1-phenyl-1H-﹤WBR>benzimidazolium, or Akt Inhibitor IV, is a cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activatio﹤WBR>n by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC﹤SUB>50﹤/SUB> = 0.625μM) and cell proliferation (IC﹤SUB>50﹤/SUB> ﹤ 1.25μM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors, this inhibitor does not affect PI3K.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5 mg in glass bottle