Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
Oleoyl-L-α-lysophosphatidic acid sodium salt has been used:for the activation of Ras homolog gene family, member A (RhoA) and expression of claudin-1 in human breast cancer epithelial cell linein RH7777 cells for cyclic adenosine monophosphate (cAMP) accumulation assay and calcium mobilisation assayin vitro luciferase assay and live-cell imaging
Biochem/physiol Actions
Endogenous agonist for LPA1 and LPA2 receptors. LPA does not induce angiogenesis, but has effects on endothelial cell physiology that are similar to those of sphingosine 1-phosphate. Induces cell migration of cancer and non-cancer cells.
Caution
Hygroscopic, photosensitive
Features and Benefits
This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
General description
Lysophosphatidic acid (LPA) is an essential metabolite for membrane biosynthesis. LPA interacts with the G protein-coupled receptors (GPCRs), called the LPA receptor and mediates signaling. Oleoyl-L-α-lysophosphatidic acid activates the receptor LPA4. In keratinocytes, oleoyl-L-α-lysophosphatidic acid promotes growth to some extent.
Packaging
1, 5, 25 mg in glass bottle
Preparation Note
Prepared by the action of phospholipase A on L-α-phosphatidic acid, dioleoyl.
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