Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

DNA intercalator. Also used to increase transfection efficiency.Chloroquine diphosphate salt has been used :in in vitro antiplasmodial assays in transfection and infection assaysin autophagy inhibitionin differentiation of induced pluripotent stem (iPS) cells into cardiomyocytesin flow treatment of infected blood

Biochem/physiol Actions

Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labeling of MRP by quinoline-based photoactive drug IAAQ (N-[4-[1-hydroxy-2-(dibutylamino)ethyl]quinolin-8-yl]-4-azidosalicylamide).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus.

Packaging

25, 50, 100, 250 g in glass bottle