Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) has been used as a:cathepsin inhibitor to study its effects on dendritic cellspapain-like cysteine protease inhibitor to study its effects on cadmium-induced mitochondrial apoptosiscysteine protease inhibitor to study its effects on the interaction of toll-like receptor 9 (TLR9) with granulin in RAW macrophages

Biochem/physiol Actions

Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteases, such as cathepsin B and L. It can also inhibit recombinant effector caspases 2, -3, -6, and -7 and not initiator caspases 8 and -10. Z-FA-FMK plays a role in blocking nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) transactivation. It exhibits therapeutic effects against rheumatoid arthritis.