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Analysis Note

ControlRat brain tissue lysate

Application

Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected PSD95 in rat cortex tissue.

Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC. (Maeda, T., et al. (2005). Invest. Ophthalmol. Vis. Sci. 46(11):4320-4327.)

Research CategoryNeuroscience

Research Sub CategoryNeurotransmitters & Receptors

Detect PSD95 using this Anti-PSD95 Antibody, clone K28/43 validated for use in IH, WB & IC.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

PSD95 (postsynaptic density 95) represent a class of anchoring proteins which serve to localize various neuronal ion channels to post-synaptic densities. PSD95 and related proteins contain PDZ domains, which interact with NMDA receptors and voltage-gated K+ channels via a ET/SXV motif in the cytoplasmic carboxyl terminus of the receptor channels.

Immunogen

Recombinant protein corresponding to human PSD95.

Linkage

Replaces: 04-1066

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blot in rat brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected PSD95 on 10 µg of rat brain tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~95 kDa observed.