Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

ED₅₀ = 0.5-2.5 ng/ml as measured in a cell proliferation assay using a human factor-dependent cell line, TF-1

General description

Recombinant, human interleukin-13 expressed in E. coli. Pleiotropic cytokine that shares many of the properties of IL-4. Exhibits IL-4-like activities on monocytes/macrophages and human B cells but has no effect on T cells. A potent regulator of STAT6 and JAK3 in NK and T cells. Regulates inflammatory and immune responses. Inhibits inducible nitric oxide synthase in human mesangial cells.

Recombinant, human interleukin-13 expressed in E. coli. Pleiotropic cytokine that shares many of the properties of IL-4. Exhibits IL-4-like activities on monocytes/macrophages and human B cells but has no effect on T cells. Potent regulator of inflammatory and immune responses. Inhibits inducible nitric oxide synthase in human mesangial cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Yu, C.R., et al. 1998. J. Immunol. 161, 218.Saura, M., et al. 1996. Biochem. J. 313, 641.Xi, X., et al. 1995. Br. J. Haematol. 90, 921.Zurawski, G., and DeVries, J.E. 1994. Stem Cells 12, 169.McKenzie, A.N.J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3735.Minty, A., et al. 1993. Nature 362, 248.

Packaging

5 µg in Plastic ampoule

Physical form

Lyophilized from sterile-filtered PBS, pH 7.4.

Reconstitution

Reconstitute to a concentration of ≥5 µg/ml with sterile PBS.

Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C. Avoid freeze/thaw cycles of solutions.

Warning

Toxicity: Standard Handling (A)