Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

WR304 is an antibody that binds specifically to the lipids 3-sn-phosphatidylinositol-4-phosphate (PIP) and PIP₂. WR304 neutralizes infectious human immunodeficiency virus (HIV-1 virus). WR304 interacts with sulfatide and not with neutral glycolipids. It is effective in neutralizing human peripheral blood mononuclear cells (PBMC) associated infections. WR304 can be used to probe the presence of PIP and PIP₂ in membranes in a variety of applications including inositol phosphate-dependent cell signaling pathways. WR304-Biotin allows this antibody to be used in combination with a wide range of commercially available streptavidin-fluorophore and streptavidin-enzyme complexes. WR304-Biotin can also be used with samples that contain mouse IgM.

General description

WR304 is an antibody that binds specifically to the lipids PIP and PIP2. WR304 also neutralizes infectious HIV-1 virus and can be used to probe the presence of PIP and PIP2 in membranes in a variety of applications including inositol phosphate-dependent cell signaling pathways. WR304-Biotin allows this antibody to be used in combination with a wide range of commercially available streptavidin-fluorophore and streptavidin-enzyme complexes. WR304-Biotin can also be used with samples that contain mouse IgM.This antibody was developed by the Walter Reed Army Institute of Research (WRAIR) using a targeted adjuvant protocol with liposomes containing Avanti’;s Lipid A.

The 3-sn-phosphatidylinositol-4-phosphate (PIP) and lipid A adjuvant, are component of WR304. WR304 mAb-biotinylated antibody was developed by the Walter Reed Army Institute of Research (WRAIR).

Packaging

0.5 mL Polypropylene Tube with Screw Cap (330022S-25ug)