G 418 solution de sel de disulfate, 50 mg/ mL in H2O, avec filtre stérile, bioréactif, convient à la culture cellulaire

Code: g8168-100ml D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

G418 disulfate is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells. Optimal ...

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£658.00 100ML

£789.60 inc. VAT

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Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

G418 disulfate is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 µg/mL or less while animal cells may require 300-500 µg/mL.

Biochem/physiol Actions

Mode of Action: G418 blocks polypeptide synthesis and protein elongation by inhibiting synthesis at the 70S and 80S ribosomes.Antimicrobial Spectrum: G418 selects for cells stably transfected with an iNOS promoter construct and neomycin resistance gene and shows activity against protozoa and helminthes.

Caution

The product is stable for two years when stored at 2-8°C.

General description

Chemical structure: aminoglycoside

antibiotic activity spectrum	parasites
biological source	Micromonospora echinospora
color	colorless
concentration	50 mg/mL in H₂O
form	solution
impurities	endotoxin, tested
InChI key	UHEPSJJJMTWUCP-NKCAIAFTSA-N
InChI	1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;21-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
mode of action	protein synthesis \| interferes
mol wt	692.7
packaging	pkg of 10 and 100 mL
potency	50-60 mg per mL
product line	BioReagent
Quality Level	200
SMILES string	OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](OC[C@@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H]([C@H](C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O
solubility	H₂O: 50 mg/mL, clear
sterility	0.1 µm filtered
storage temp.	2-8°C
technique(s)	cell culture \| mammalian: suitable