7alpha-Hydroxy - 4 - cholesten - 3-1

Code: 52853-1mg D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

C4 may be used as a reference standard for the determination of C4 in:Human serum by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-...


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$331.19 1MG
$397.43 inc. VAT
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

C4 may be used as a reference standard for the determination of C4 in:Human serum by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) with electrospray ionization source (ESI) as well as LC-MS.Rat and monkey plasma by LC-ESI-MS/MS working on multiple reaction monitoring (MRM) mode of detection.Peripheral blood plasma by solid-phase extraction (SPE) and HPLC.

Biochem/physiol Actions

7a-Hydroxycholestene-3-one, a metabolite in bile acid synthesis, is derived from 7a-hydroxycholesterol and can be further metabolized to 7a,12a,-dihydroxycholest-4-en-3-one. Analysis of 7a-Hydroxycholestene-3-one (HCO) in serum may serve as a novel, simple, and sensitive method for the detection of bile acid malabsorption in patients with chronic diarrhea of unknown origin.

General description

7α-Hydroxy-4-cholesten-3-one (C4) is known as a marker for the cholesterol 7α-hydroxylase activity. It plays an important role in bile acid metabolism.

application(s)clinical testing
assay≥95.0% (HPLC)
formatneat
gradeanalytical standard
InChI keyIOIZWEJGGCZDOL-RQDYSCIWSA-N
InChI1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1
Quality Level100
SMILES stringO=C1CC[C@@]2(C)C(C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)C)=C1
storage temp.−20°C
Cas Number3862-25-7
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